关键词: Valeriana jatamansi Valerianaceae cytotoxicity isomers valepotriates

Mesh : Antineoplastic Agents, Phytogenic / chemistry isolation & purification pharmacology Colonic Neoplasms / drug therapy Drug Screening Assays, Antitumor Drugs, Chinese Herbal / chemistry isolation & purification pharmacology Humans Inhibitory Concentration 50 Iridoids / chemistry isolation & purification pharmacology Isomerism Male Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots / chemistry Prostatic Neoplasms / drug therapy Valerian / chemistry

来  源:   DOI:10.1080/10286020.2016.1258065

Abstract:
Three new minor valepotriate isomers, jatamanvaltrates Z1 (1), Z2 (2), and Z3 (3), have been isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii.). Their structures were elucidated by extensive spectroscopic analysis, especially 2D NMR and ESI-MS/MSn. All isolated compounds displayed moderate cytotoxicity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3 M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines with IC50 values of 2.8-8.3 μM.
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