在 BRAF 突变阳性的晚期黑色素瘤患者中优化 dabrafenib 和 trametinib 联合治疗 : 澳大利亚黑色素瘤医学肿瘤学家指南.
关键词: BRAF MEK dabrafenib melanoma pyrexia trametinib
Mesh : Antineoplastic Combined Chemotherapy Protocols / adverse effects Australia Drug Eruptions / etiology therapy Exanthema / chemically induced therapy Fever / chemically induced therapy Humans Imidazoles / administration & dosage adverse effects MAP Kinase Kinase Kinases / antagonists & inhibitors Medical Oncology / methods Melanoma / drug therapy genetics Mutation Oximes / administration & dosage adverse effects Practice Guidelines as Topic Proto-Oncogene Proteins B-raf / antagonists & inhibitors genetics Pyridones / administration & dosage adverse effects Pyrimidinones / administration & dosage adverse effects Skin Neoplasms Melanoma, Cutaneous Malignant