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Abstract：
Fluorescent materials are widely used in biological and material applications as probes for imaging or sensing; however, their customization is usually complicated without the support of an organic chemistry laboratory. Here, we present a straightforward method for the customization of BODIPY cores, which are among the most commonly used fluorescent probes. The method is based on the formation of a new C-C bond through Friedel-Crafts electrophilic aromatic substitution carried out at room temperature. The method presented can be used to obtain completely customized fluorescent materials in one or two steps from commercially available compounds. Examples of the preparation of fluorescent materials for cell staining and functionalization of silica colloids are also presented.
摘要：
荧光材料广泛用于生物和材料应用，作为成像或传感的探针；然而，他们的定制通常是复杂的，没有有机化学实验室的支持。这里,我们提出了一种定制BODIPY内核的简单方法，其中最常用的荧光探针。该方法基于在室温下通过Friedel-Crafts亲电子芳族取代形成新的C-C键。所提出的方法可用于在一个或两个步骤中从市售化合物获得完全定制的荧光材料。还提供了用于细胞染色和二氧化硅胶体功能化的荧光材料的制备实例。
