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Abstract：
Literature on the health-related quality of life (HRQoL) for men with localized prostate cancer (PCa) on active surveillance (AS) shows a need for methodological guidance regarding HRQoL issues and how to address them.
The European School of Oncology Task Force (ESO TF) aimed to identify a core set of research questions and related measures to include in AS HRQoL studies.
A modified Delphi study was used to reach consensus on AS HRQoL research topics and tools between 2014 and 2015. Data were collected by engaging a multidisciplinary team of 15 experts.
An open-ended questionnaire was used to collect information from ESO TF members regarding issues in AS HRQoL research. Then a structured questionnaire was used to collect ratings on the usefulness/importance of different AS HRQoL aspects. Items that ≥80% of ESO TF members rated as useful/important were retained. Items with a 50-80% rating were discussed to reach final agreement.
Six main research questions concerning the selection of outcome measures, measurement tools, and comparison groups were identified as relevant. The core set of measures identified were related to individual characteristics, psychological dimensions; decision-making-related issues, and physical functioning. The multidisciplinary expertise of ESO TF members was a significant asset, even if bringing different backgrounds to the discussion table represented a challenge.
HRQoL measures have to be sensitive to the specific needs of men on AS. The definition of HRQoL outcomes will enhance a broader understanding of the HRQoL of men on AS and sustain patient-centered medicine.
An international panel agreed on a set of health-related quality-of-life aspects to be assessed among men on active surveillance for prostate cancer. Valid relevant questionnaires were identified. The experts\' indications lay a foundation for future research and clinical practice.
The European School of Oncology Task Force (ESO TF) aimed to identify a core set of research questions and related measures to include in AS HRQoL studies.
A modified Delphi study was used to reach consensus on AS HRQoL research topics and tools between 2014 and 2015. Data were collected by engaging a multidisciplinary team of 15 experts.
An open-ended questionnaire was used to collect information from ESO TF members regarding issues in AS HRQoL research. Then a structured questionnaire was used to collect ratings on the usefulness/importance of different AS HRQoL aspects. Items that ≥80% of ESO TF members rated as useful/important were retained. Items with a 50-80% rating were discussed to reach final agreement.
Six main research questions concerning the selection of outcome measures, measurement tools, and comparison groups were identified as relevant. The core set of measures identified were related to individual characteristics, psychological dimensions; decision-making-related issues, and physical functioning. The multidisciplinary expertise of ESO TF members was a significant asset, even if bringing different backgrounds to the discussion table represented a challenge.
HRQoL measures have to be sensitive to the specific needs of men on AS. The definition of HRQoL outcomes will enhance a broader understanding of the HRQoL of men on AS and sustain patient-centered medicine.
An international panel agreed on a set of health-related quality-of-life aspects to be assessed among men on active surveillance for prostate cancer. Valid relevant questionnaires were identified. The experts\' indications lay a foundation for future research and clinical practice.
摘要：
有关主动监测（AS）的局限性前列腺癌（PCa）男性与健康相关的生活质量（HRQoL）的文献表明，需要有关HRQoL问题以及如何解决这些问题的方法学指导。
欧洲肿瘤学学院工作组（ESOTF）旨在确定一组核心研究问题和相关措施，以纳入ASHRQoL研究。
在2014年至2015年之间，使用了改良的Delphi研究就ASHRQoL研究主题和工具达成共识。通过聘请由15名专家组成的多学科小组收集数据。
使用开放式问卷从ESOTF成员那里收集有关ASHRQoL研究中问题的信息。然后使用结构化问卷来收集对不同ASHRQoL方面的有用性/重要性的评级。保留≥80%的ESOTF成员被评为有用/重要的项目。讨论了50-80％评级的项目，以达成最终协议。
关于结果指标选择的六个主要研究问题，测量工具,和比较组被确定为相关的。确定的核心指标集与个体特征有关，心理维度；决策相关问题，和身体功能。ESOTF成员的多学科专业知识是一项重要资产，即使在讨论桌上带来不同的背景也是一个挑战。
HRQoL措施必须对男性的特定需求敏感。HRQoL结果的定义将增强对AS患者HRQoL的更广泛理解，并维持以患者为中心的医学。
一个国际小组就一系列与健康相关的生活质量方面达成了一致，将对男性进行前列腺癌积极监测。确定了有效的相关问卷。专家的适应症为今后的研究和临床实践奠定了基础。
欧洲肿瘤学学院工作组（ESOTF）旨在确定一组核心研究问题和相关措施，以纳入ASHRQoL研究。
在2014年至2015年之间，使用了改良的Delphi研究就ASHRQoL研究主题和工具达成共识。通过聘请由15名专家组成的多学科小组收集数据。
使用开放式问卷从ESOTF成员那里收集有关ASHRQoL研究中问题的信息。然后使用结构化问卷来收集对不同ASHRQoL方面的有用性/重要性的评级。保留≥80%的ESOTF成员被评为有用/重要的项目。讨论了50-80％评级的项目，以达成最终协议。
关于结果指标选择的六个主要研究问题，测量工具,和比较组被确定为相关的。确定的核心指标集与个体特征有关，心理维度；决策相关问题，和身体功能。ESOTF成员的多学科专业知识是一项重要资产，即使在讨论桌上带来不同的背景也是一个挑战。
HRQoL措施必须对男性的特定需求敏感。HRQoL结果的定义将增强对AS患者HRQoL的更广泛理解，并维持以患者为中心的医学。
一个国际小组就一系列与健康相关的生活质量方面达成了一致，将对男性进行前列腺癌积极监测。确定了有效的相关问卷。专家的适应症为今后的研究和临床实践奠定了基础。
