关键词： DKK Wnt pathway lung cancer

Mesh ： Alleles Case-Control Studies Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Haplotypes Humans India / epidemiology Intercellular Signaling Peptides and Proteins / genetics Linkage Disequilibrium Lung Neoplasms / diagnosis epidemiology genetics Male Neoplasm Metastasis Neoplasm Staging Polymorphism, Single Nucleotide Risk Risk Factors Tumor Burden

来  源：   DOI：10.2217/fon-2016-0117   PDF(Sci-hub)

Abstract：
OBJECTIVE: To investigate the association between the genetic variants of DKK4 (rs2073664), DKK3 (rs2291599, rs3206824 and rs7391689) and DKK2 (rs447372, rs419558 and rs17037102) and lung cancer predisposition in north Indians.
METHODS: A total of 600 subjects were genotyped using PCR restriction fragment length polymorphism technique. Association analysis was carried out using logistic regression approach.
RESULTS: DKK3 rs7396187 showed a protective effect (p = 0.01). Subjects with heterozygous genotype of DKK2 rs17037102 and rs419558 showed an increased risk. The variant genotype of the genotypic combination, DKK3 rs3206824 and DKK2 rs419558 showed a twofold increased risk (p = 0.008). Lung cancer risk increased four-times in subjects with variant genotype of all the three DKK2 variants.
CONCLUSIONS: DKK2 is certainly playing a crucial role in modulating cancer susceptibility.
摘要：
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