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Abstract：
OBJECTIVE: To examine the association between venous thromboembolism and prolonged work- and computer-related seated immobility.
METHODS: A case-control study.
METHODS: Cases were 200 patients attending venous thromboembolism clinics with a history of deep vein thrombosis and/or pulmonary embolism in the past six months, and controls were 200 patients treated in fracture clinic for an upper limb injury in the past six months.
METHODS: Logistic regression was used to estimate the association between venous thromboembolism and prolonged work- and computer-related seated immobility in the 28 days before the index event. Prolonged work- and computer-related seated immobility was defined firstly as a categorical variable with at least 10 h seated in a 24-h period, including at least 2 h without getting up; and secondly as the actual time spent seated in a 24-h period.
RESULTS: Prolonged work- and computer-related seated immobility (categorical variable) was present in 36 (18%) cases and 31 (15.5%) controls. In multivariate analysis, there was no significant association between prolonged seated immobility and venous thromboembolism, odds ratio 1.18 (95% CI 0.56 to 2.48), P = 0.67. For the mean and maximum number of hours seated in a 24-h period, the odds ratios for the association per additional hour seated with venous thromboembolism were 1.08 (95% CI 1.01 to 1.6), P = 0.02 and 1.04 (95% CI 0.99 to 1.09), P = 0.08, respectively.
CONCLUSIONS: This study found a weak association between venous thromboembolism and prolonged work- and computer-related seated immobility, with increasing mean hours seated associated with a higher risk of venous thromboembolism.
METHODS: A case-control study.
METHODS: Cases were 200 patients attending venous thromboembolism clinics with a history of deep vein thrombosis and/or pulmonary embolism in the past six months, and controls were 200 patients treated in fracture clinic for an upper limb injury in the past six months.
METHODS: Logistic regression was used to estimate the association between venous thromboembolism and prolonged work- and computer-related seated immobility in the 28 days before the index event. Prolonged work- and computer-related seated immobility was defined firstly as a categorical variable with at least 10 h seated in a 24-h period, including at least 2 h without getting up; and secondly as the actual time spent seated in a 24-h period.
RESULTS: Prolonged work- and computer-related seated immobility (categorical variable) was present in 36 (18%) cases and 31 (15.5%) controls. In multivariate analysis, there was no significant association between prolonged seated immobility and venous thromboembolism, odds ratio 1.18 (95% CI 0.56 to 2.48), P = 0.67. For the mean and maximum number of hours seated in a 24-h period, the odds ratios for the association per additional hour seated with venous thromboembolism were 1.08 (95% CI 1.01 to 1.6), P = 0.02 and 1.04 (95% CI 0.99 to 1.09), P = 0.08, respectively.
CONCLUSIONS: This study found a weak association between venous thromboembolism and prolonged work- and computer-related seated immobility, with increasing mean hours seated associated with a higher risk of venous thromboembolism.
摘要：
目的：研究静脉血栓栓塞与长期工作和计算机相关的坐位不动之间的关系。
方法：病例对照研究。
方法：病例为200名在过去6个月内有深静脉血栓形成和/或肺栓塞病史的患者，对照组是过去6个月在骨折诊所接受上肢损伤治疗的200例患者。
方法：使用Logistic回归评估静脉血栓栓塞与指征事件发生前28天内长时间工作和计算机相关的坐位不动之间的关系。长期工作和计算机相关的坐姿不动首先被定义为一个分类变量，在24小时内至少坐10小时，包括至少2小时不起床;其次是在24小时内坐着的实际时间。
结果：36例（18％）和31例（15.5％）对照中存在与工作和计算机相关的长期坐位不动（分类变量）。在多变量分析中，长期坐位不动和静脉血栓栓塞之间没有显著关联,优势比1.18（95%CI0.56至2.48），P=0.67。对于24小时内的平均和最大就座小时数，静脉血栓栓塞每增加1小时的关联比值比为1.08(95%CI1.01~1.6),P=0.02和1.04（95%CI0.99至1.09），P分别=0.08。
结论：这项研究发现静脉血栓栓塞与长时间工作和计算机相关的坐位不动之间存在弱关联，随着平均坐位时间的增加，静脉血栓栓塞的风险更高。
方法：病例对照研究。
方法：病例为200名在过去6个月内有深静脉血栓形成和/或肺栓塞病史的患者，对照组是过去6个月在骨折诊所接受上肢损伤治疗的200例患者。
方法：使用Logistic回归评估静脉血栓栓塞与指征事件发生前28天内长时间工作和计算机相关的坐位不动之间的关系。长期工作和计算机相关的坐姿不动首先被定义为一个分类变量，在24小时内至少坐10小时，包括至少2小时不起床;其次是在24小时内坐着的实际时间。
结果：36例（18％）和31例（15.5％）对照中存在与工作和计算机相关的长期坐位不动（分类变量）。在多变量分析中，长期坐位不动和静脉血栓栓塞之间没有显著关联,优势比1.18（95%CI0.56至2.48），P=0.67。对于24小时内的平均和最大就座小时数，静脉血栓栓塞每增加1小时的关联比值比为1.08(95%CI1.01~1.6),P=0.02和1.04（95%CI0.99至1.09），P分别=0.08。
结论：这项研究发现静脉血栓栓塞与长时间工作和计算机相关的坐位不动之间存在弱关联，随着平均坐位时间的增加，静脉血栓栓塞的风险更高。
