PDF(Pubmed)
Abstract：
Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate\'s innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse. To understand the addictive properties of morphine, past studies have focused on relevant molecular and cellular changes in the brain, highlighting the functional roles of reward-related brain regions. Given the accumulated findings, a recent, emerging trend in morphine research is that of examining the dynamics of neuronal interactions in brain reward circuits under the influence of morphine action. In this review, we highlight recent findings on the roles of several reward circuits involved in morphine addiction based on pharmacological, molecular and physiological evidences.
摘要：
吗啡是治疗慢性疼痛最有效的镇痛药,但其临床使用受到阿片类药物产生耐受性的先天倾向的限制，严重的戒断症状和具有高复发风险的有益性质。为了了解吗啡的成瘾性,过去的研究集中在大脑中相关的分子和细胞变化，突出奖励相关大脑区域的功能作用。鉴于累积的发现，最近，吗啡研究的新趋势是在吗啡作用的影响下检查大脑奖励回路中神经元相互作用的动力学。在这次审查中,我们强调最近发现的作用的几个奖励电路参与吗啡成瘾的药理学基础上，分子和生理证据。
