Methotrexate induced pneumatosis intestinalis under hemodialysis patient.

• 影响指数: 1.543
• 发表时间: 01 2017
• 来源期刊: Hemodial Int
• DOI: 10.1111/hdi.12459
• PMID: 27381347
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Mima A,Nagahara D,Tansho K

关键词: Pneumatosis intestinalis (PI); chronic kidney disease (CKD); hemodialysis (HD); methotrexate (MTX)

Mesh: Antirheumatic Agents / adverse effects; Humans; Male; Methotrexate / adverse effects; Middle Aged; Pneumatosis Cystoides Intestinalis / chemically induced; Renal Dialysis / adverse effects

Abstract

Pneumatosis intestinalis (PI) is a rare disorder characterized by the gas within the intestinal mucosa. This is the first report methotrexate (MTX) induced PI under hemodialysis (HD) patient. A 46-year-old man suffered rheumatoid arthritis and underwent HD at local HD center. After the initial induction of MTX, the patient showed epigastralgia and diarrhea. He was referred to our hospital and abdominal computed tomography showed significant large intestinal edema and free intraperitoneal air consistent with PI. Physicians should aware that MTX is contraindication drug for chronic kidney disease and high-flux HD may decrease MTX toxicity and oxidative stress, improving PI.