Mesh ： Adult Antineoplastic Combined Chemotherapy Protocols / administration & dosage Dactinomycin / administration & dosage Doxorubicin / administration & dosage Etoposide / administration & dosage Female Hemorrhage / etiology Humans Hydatidiform Mole, Invasive / complications drug therapy Kidney Diseases / etiology Leucovorin / administration & dosage Methotrexate / administration & dosage Pregnancy Uterine Neoplasms / complications drug therapy Vincristine / administration & dosage

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Abstract：
METHODS: The authors report a case with spontaneous renal hemorrhage caused by invasive mole. The diagnosis was gestational trophoblastic disease (GTD), with metastasis to brain, kidneys, and lungs at Stage IV. The patient was given etoposide-methotrexate-actinomycin D plus cyclophosphamide-vincristine (EMACO) treatment regimen for 11 times including three times with consolidation chemotherapies. Laparoscopically-assisted vaginal hysterectomy (LAVH) + laparoscopic-assisted left renal excision + evacuation of the left perirenal hematoma were performed during the eighth chemotherapy.
CONCLUSIONS: Post-operational pathological examination revealed trophoblasts within the lesions present in uterine fundus and the residue images of a few trophoblasts present in the left renal mass.
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