METHODS: (1) H NMR microscopy was utilized to investigate histological changes and/or skin pathology between normal skin and abnormal skin. Animal skin was used for both in vivo and in vitro investigations while human skin for the in vivo study.
RESULTS: Relaxation times and diffusion information were found to be sensitive indicators of the biochemical changes arising from epidermis due to skin abnormality. Also, the swelling process of abnormal epidermis was monitored.
CONCLUSIONS: Dermal NMR microscopy was found useful for the study of the biochemical changes occurring in thin skin layers.