Abstract：
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8(+) cells and granulysin-bearing cells and lower numbers of CD206(+) cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.
摘要：
默克尔细胞癌（MCC）是一种侵袭性神经内分泌癌，很少自发消退。由于对MCC自发消退的免疫学机制知之甚少，我们描述了一例自发消退的MCC病例,并对细胞毒性和免疫抑制分子进行了免疫组织化学染色,以研究参与MCC自发消退的可能机制.有趣的是,与传统的MCC相比，自发消退的MCC中的肿瘤浸润淋巴细胞包含较高数量的CD8（）细胞和带有颗粒溶素的细胞，而较低数量的CD206（）细胞。我们目前的研究表明了MCC自发消退的可能原因之一。
