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Abstract：
Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.
摘要：
丛状纤维组织肿瘤（PFT）是一种罕见的中间恶性潜能的间质性肿瘤，局部复发率高。在这份报告中,我们描述了耳朵上的PFT，这表明骨膜素（POSTN）在肿瘤的间质区域密集沉积。此外,在与POSTN相同的区域检测到CD163+CD206-肿瘤相关巨噬细胞(TAMs)的密集浸润。由于POSTN以前被报道对TAM具有免疫调节作用，本报告提示POSTN/TAMs轴在PFT进展中的意义.
