Abstract：
\"Epitope matching\" has become a buzz word in solid organ transplantation. Its goal is to improve matching between donor and recipient, to minimize risk for antibody-mediated rejection and to reduce sensitization associated with graft failure. Current software allows identification and enumeration of amino acid sequence mismatches in the form of HLA eplets; however, \"eplets\" and \"epitopes\" are not interchangeable terms, and the understanding of what contributes to the antigenicity and immunogenicity of HLA B cell epitopes is still very limited and inadequate. In fact, we still do not know what constitutes an HLA epitope or how to define it in a clinically useful way. To allow for judicious implementation of epitope matching, it is critical to explore the full spectrum of factors that affect allorecognition. In exploring antibody-binding patterns, we have uncovered a potential tool-currently hidden in plain sight-that may shed light on some aspects of epitope characteristics.
摘要：
“表位匹配”已成为实体器官移植中的流行语。它的目标是改善捐赠者和接受者之间的匹配，将抗体介导的排斥反应的风险降至最低，并减少与移植物失败相关的致敏作用。当前的软件允许鉴定和列举HLA小蛋白形式的氨基酸序列错配；然而，\"eplets\"和\"表位\"是不可互换的术语，对HLAB细胞表位的抗原性和免疫原性的理解仍然非常有限和不足。事实上,我们仍然不知道什么构成HLA表位或如何以临床有用的方式定义它。为了明智地实施表位匹配，探索影响同种异体识别的全部因素是至关重要的。在探索抗体结合模式时，我们发现了一种潜在的工具-目前隐藏在普通的视野中-可能会揭示表位特征的某些方面。
