Pca1p 的内质网相关降解 ,多才多艺的蛋白质 ,通过与膜上的蛋白酶体相互作用。
关键词: ATPase cadmium transporter degron endoplasmic reticulum-associated protein degradation (ERAD) membrane protein metal homeostasis proteasome ubiquitin ligase yeast
Mesh : ATP-Binding Cassette Transporters / genetics metabolism Adenosine Triphosphatases / genetics metabolism Cation Transport Proteins / genetics metabolism Cell Cycle Proteins / metabolism Cytosol / metabolism Endoplasmic Reticulum / metabolism Endoplasmic Reticulum-Associated Degradation Hydroxymethylglutaryl CoA Reductases / genetics metabolism Leupeptins / pharmacology Proteasome Endopeptidase Complex / metabolism Proteasome Inhibitors / pharmacology Recombinant Fusion Proteins / genetics metabolism Saccharomyces cerevisiae / drug effects genetics metabolism Saccharomyces cerevisiae Proteins / genetics metabolism Ubiquitin-Conjugating Enzymes / genetics metabolism Ubiquitin-Protein Ligases / metabolism Ubiquitination Valosin Containing Protein
来 源:
DOI:10.1074/jbc.M116.726265
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