Replication protein A and more: single-stranded DNA-binding proteins in eukaryotic cells.

• 影响指数: 3.511
• 发表时间: Jul 2016
• 来源期刊: Acta Biochim Biophys Sin (Shanghai)
• DOI: 10.1093/abbs/gmw041
• PMID: 27151292
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 生物
• 作者列表: Liu T,Huang J

关键词: genome instability; replication protein A; sensor of single-stranded DNA complex; single-stranded DNA-binding proteins

Mesh: Animals; DNA Repair; DNA-Binding Proteins / metabolism; Eukaryotic Cells; Genomic Instability; Humans; Replication Protein A / metabolism

Abstract

Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication, recombinational repair, and maintenance of genome stability. In human, the major SSB, replication protein A (RPA), is a stable heterotrimer composed of subunits of RPA1, RPA2, and RPA3, each of which is conserved not only in mammals but also in all other eukaryotic species. In addition to RPA, other SSBs have also been identified in the human genome, including sensor of single-stranded DNA complexes 1 and 2 (SOSS1/2). In this review, we summarize our current understanding of how these SSBs contribute to the maintenance of genome stability.