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Abstract：
Myosins are a large family of molecular motors that use the common P-loop, Switch 1 and Switch 2 nucleotide binding motifs to recognize ATP, to create a catalytic site than can efficiently hydrolyze ATP and to communicate the state of the nucleotide pocket to other allosteric binding sites on myosin. The energy of ATP hydrolysis is used to do work against an external load. In this short review I will outline current thinking on the mechanism of ATP hydrolysis and how the energy of ATP hydrolysis is coupled to a series of protein conformational changes that allow a myosin, with the cytoskeleton track actin, to operate as a molecular motor of distinct types; fast movers, processive motors or strain sensors. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 483-491, 2016.
摘要：
肌球蛋白是一个使用常见P环的分子马达大家族，开关1和开关2核苷酸结合基序识别ATP，创建一个催化位点，可以有效地水解ATP，并将核苷酸口袋的状态传达给肌球蛋白上的其他变构结合位点。ATP水解的能量用于对抗外部负荷。在这篇简短的综述中，我将概述目前对ATP水解机制的思考，以及ATP水解的能量如何与一系列蛋白质构象变化耦合，从而允许肌球蛋白，与细胞骨架轨道肌动蛋白，作为不同类型的分子马达运行；快速移动者，渐进式电机或应变传感器。©2016威利期刊，公司。生物聚合物105:483-491，2016。
