在果蝇中有效表达双链 piRNA 簇需要 TREX 在新生 RNA 上的剪接非依赖性装载。
关键词: TREX Thoc5 mRNA loading piRNA biogenesis transcriptional regulation
Mesh : Animals Body Patterning / genetics Cell Nucleus / metabolism Drosophila Proteins / biosynthesis genetics metabolism Drosophila melanogaster / physiology Female Fertility / genetics Gene Expression Regulation, Developmental Male Multiprotein Complexes / genetics metabolism Mutation Nuclear Proteins / genetics metabolism Protein Transport RNA Precursors / metabolism RNA, Small Interfering / biosynthesis genetics RNA-Binding Proteins / metabolism
来 源:
DOI:10.1101/gad.276030.115
PDF(Sci-hub)