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Abstract：
BACKGROUND: Mitotic spindle apparatus (MSA) antibodies are rare findings with undefined clinical significance in clinical research. We aimed at investigating the prevalence and clinical significance of anti-MSA antibodies in Chinese population.
METHODS: Between 2008 and 2013, a total of 180,180 patients were studied for the presence of anti-MSA antibodies. The clinical details and laboratory data of anti-MSA-positive patients were retrospectively collected and analyzed.
RESULTS: Of the 180,180 patients tested, 68,640 patients presented with positive antinuclear antibodies (ANAs, 38.10%), but only 32 patients with positive anti-MSA antibodies (0.018%). Diagnoses were established in 22 of 32 patients: 16 connective tissue diseases (CTDs), mainly Sjogren syndrome (SS, 5/16), rheumatoid arthritis (RA, 4/16), and systemic lupus erythematosus (SLE, 3/16), and 6 nonautoimmune conditions. The most frequent clinical symptoms of the anti-MSA-positive patients were arthralgia and eyes and mouth drying. Additionally, 70% of anti-MSA antibodies were not associated with other ANAs, however, when associated, the most frequent ANA was anti-SSA.
CONCLUSIONS: Anti-MSA antibodies have a low prevalence and female gender predominance. Anti-MSA antibodies are primarily associated with CTDs, mainly SS, RA, and SLE. The presence of anti-MSA antibodies might be the unique serological markers of the CTDs, especially when anti-SSA, SSB, and dsDNA antibodies are negative, or the level of RF is low.
METHODS: Between 2008 and 2013, a total of 180,180 patients were studied for the presence of anti-MSA antibodies. The clinical details and laboratory data of anti-MSA-positive patients were retrospectively collected and analyzed.
RESULTS: Of the 180,180 patients tested, 68,640 patients presented with positive antinuclear antibodies (ANAs, 38.10%), but only 32 patients with positive anti-MSA antibodies (0.018%). Diagnoses were established in 22 of 32 patients: 16 connective tissue diseases (CTDs), mainly Sjogren syndrome (SS, 5/16), rheumatoid arthritis (RA, 4/16), and systemic lupus erythematosus (SLE, 3/16), and 6 nonautoimmune conditions. The most frequent clinical symptoms of the anti-MSA-positive patients were arthralgia and eyes and mouth drying. Additionally, 70% of anti-MSA antibodies were not associated with other ANAs, however, when associated, the most frequent ANA was anti-SSA.
CONCLUSIONS: Anti-MSA antibodies have a low prevalence and female gender predominance. Anti-MSA antibodies are primarily associated with CTDs, mainly SS, RA, and SLE. The presence of anti-MSA antibodies might be the unique serological markers of the CTDs, especially when anti-SSA, SSB, and dsDNA antibodies are negative, or the level of RF is low.
摘要：
背景：有丝分裂纺锤体（MSA）抗体是临床研究中罕见的发现，临床意义不明确。我们旨在调查中国人群中抗MSA抗体的患病率和临床意义。
方法：在2008年至2013年之间，研究了180,180名患者是否存在抗MSA抗体。回顾性收集和分析抗MSA阳性患者的临床细节和实验室资料。
结果：在接受测试的180,180名患者中，68,640名患者出现抗核抗体阳性(ANA，38.10%），但只有32例抗MSA抗体阳性的患者（0.018％）。32例患者中有22例确诊：16例结缔组织病（CTDs），主要是干燥综合征（SS，5/16),类风湿性关节炎（RA，4/16),和系统性红斑狼疮（SLE，3/16),和6种非自身免疫性疾病。抗MSA阳性患者最常见的临床症状是关节痛和眼睛和口腔干燥。此外,70%的抗MSA抗体与其他ANAs无关，然而,当关联时，最常见的ANA是抗SSA。
结论：抗MSA抗体的患病率较低，女性占主导地位。抗MSA抗体主要与CTD相关，主要是SS,RA,和SLE。抗MSA抗体的存在可能是CTD的独特血清学标志物，尤其是在抗SSA时,SSB,dsDNA抗体是阴性的，或RF水平低。
方法：在2008年至2013年之间，研究了180,180名患者是否存在抗MSA抗体。回顾性收集和分析抗MSA阳性患者的临床细节和实验室资料。
结果：在接受测试的180,180名患者中，68,640名患者出现抗核抗体阳性(ANA，38.10%），但只有32例抗MSA抗体阳性的患者（0.018％）。32例患者中有22例确诊：16例结缔组织病（CTDs），主要是干燥综合征（SS，5/16),类风湿性关节炎（RA，4/16),和系统性红斑狼疮（SLE，3/16),和6种非自身免疫性疾病。抗MSA阳性患者最常见的临床症状是关节痛和眼睛和口腔干燥。此外,70%的抗MSA抗体与其他ANAs无关，然而,当关联时，最常见的ANA是抗SSA。
结论：抗MSA抗体的患病率较低，女性占主导地位。抗MSA抗体主要与CTD相关，主要是SS,RA,和SLE。抗MSA抗体的存在可能是CTD的独特血清学标志物，尤其是在抗SSA时,SSB,dsDNA抗体是阴性的，或RF水平低。
