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Abstract：
BACKGROUND: Intra-articular injection of corticosteroids (IIC) for treatment of patients with juvenile idiopathic arthritis (JIA) is increasingly used in Pediatric Rheumatology.
OBJECTIVE: To describe the clinical course of patients undergoing IIC in our Pediatric Rheumatology Unit.
METHODS: Retrospective study of patients with JIA undergoing IIC from January 2008 to December 2012, with a minimum follow-up of six months after the injection. Good response to IIC was set as the presence of inactivity on the infiltrated joint by at least six months.
RESULTS: Eighty-eight patients underwent a total of 165 IICs. Of these, 75% were girls and 35.2% had persistent oligoarticular JIA. The mean age at diagnosis was 6.8 years, and when IIC was carried out, 12.2 years. Regarding patients, younger age at diagnosis (p=0.037) and the occurrence of uveitis in the course of the disease (p=0.015) were associated with good response to IIC. From 165 IICs, 63% had a good response and joints remained inactive for a median of 18.1 months. The type of joint injection (p=0.001), lesser values stated in the overall visual analogue scale by the physician (p=0.015) and by parents/patient (p=0.01) have been associated with a good response to IIC. Nine adverse events (5.4%) were observed.
CONCLUSIONS: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure.
OBJECTIVE: To describe the clinical course of patients undergoing IIC in our Pediatric Rheumatology Unit.
METHODS: Retrospective study of patients with JIA undergoing IIC from January 2008 to December 2012, with a minimum follow-up of six months after the injection. Good response to IIC was set as the presence of inactivity on the infiltrated joint by at least six months.
RESULTS: Eighty-eight patients underwent a total of 165 IICs. Of these, 75% were girls and 35.2% had persistent oligoarticular JIA. The mean age at diagnosis was 6.8 years, and when IIC was carried out, 12.2 years. Regarding patients, younger age at diagnosis (p=0.037) and the occurrence of uveitis in the course of the disease (p=0.015) were associated with good response to IIC. From 165 IICs, 63% had a good response and joints remained inactive for a median of 18.1 months. The type of joint injection (p=0.001), lesser values stated in the overall visual analogue scale by the physician (p=0.015) and by parents/patient (p=0.01) have been associated with a good response to IIC. Nine adverse events (5.4%) were observed.
CONCLUSIONS: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure.
摘要：
背景：关节内注射皮质类固醇（IIC）用于治疗幼年特发性关节炎（JIA）患者越来越多地用于小儿风湿病。
目的：描述在我们儿科风湿病室接受IIC的患者的临床过程。
方法：对2008年1月至2012年12月接受IIC的JIA患者进行回顾性研究，注射后最少随访6个月。对IIC的良好反应被设定为在至少6个月内浸润的关节上存在不活动。
结果：88例患者共接受了165例IIC。其中,75％是女孩，35.2％患有持续性少关节JIA。诊断时的平均年龄为6.8岁，当IIC被执行时，12.2年。关于患者，诊断时年龄较小(p=0.037)和病程中葡萄膜炎的发生(p=0.015)与对IIC的良好反应相关.来自165个IIC，63%的患者有良好的反应，关节保持不活跃的中位数为18.1个月。联合注射的类型（p=0.001），医生(p=0.015)和父母/患者(p=0.01)在总体视觉模拟量表中表示的较小值与对IIC的良好反应相关.观察到9个不良事件（5.4％）。
结论：在我们的研究中，超过一半的关节对IIC表现出良好的反应。诊断和葡萄膜炎过程中的年轻患者对IIC反应良好。膝盖，手腕和肘部是对IIC反应最好的关节。IIC被证明是一个安全的程序。
目的：描述在我们儿科风湿病室接受IIC的患者的临床过程。
方法：对2008年1月至2012年12月接受IIC的JIA患者进行回顾性研究，注射后最少随访6个月。对IIC的良好反应被设定为在至少6个月内浸润的关节上存在不活动。
结果：88例患者共接受了165例IIC。其中,75％是女孩，35.2％患有持续性少关节JIA。诊断时的平均年龄为6.8岁，当IIC被执行时，12.2年。关于患者，诊断时年龄较小(p=0.037)和病程中葡萄膜炎的发生(p=0.015)与对IIC的良好反应相关.来自165个IIC，63%的患者有良好的反应，关节保持不活跃的中位数为18.1个月。联合注射的类型（p=0.001），医生(p=0.015)和父母/患者(p=0.01)在总体视觉模拟量表中表示的较小值与对IIC的良好反应相关.观察到9个不良事件（5.4％）。
结论：在我们的研究中，超过一半的关节对IIC表现出良好的反应。诊断和葡萄膜炎过程中的年轻患者对IIC反应良好。膝盖，手腕和肘部是对IIC反应最好的关节。IIC被证明是一个安全的程序。
