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Abstract：
A promising strategy for liver cancer treatment is to deliver chemotherapeutic agents with multifunctional carriers into the tumor tissue via intra-arterial (IA) transcatheter infusion. These carriers should release drugs within the target tissue for prolonged periods and permit intra-procedural multi-modal imaging of selective tumor delivery. This targeted transcatheter delivery approach is enabled via the arterial blood supply to liver tumors and utilized in current clinical practice which is called chemoembolization or radioembolization. During our study, we developed Doxorubicin (Dox) loaded porous magnetic nano-clusters (Dox-pMNCs). The porous structure and carboxylic groups on the MNCs achieved high-drug loading efficiency and sustained drug release, along with magnetic properties resulting in high MRI T2-weighted image contrast. Dox-pMNC within iodinated oil, Dox-pMNCs, and Dox within iodinated oil were infused via hepatic arteries to target liver tumors in a rabbit model. MRI and histological evaluations revealed that the long-term drug release and retention of Dox-pMNCs within iodinated oil induced significantly enhanced liver cancer cell death.
摘要：
肝癌治疗的有希望的策略是通过动脉内（IA）经导管输注将具有多功能载体的化学治疗剂递送到肿瘤组织中。这些载体应在靶组织内长时间释放药物，并允许选择性肿瘤递送的术中多模式成像。这种靶向的经导管递送方法是通过肝肿瘤的动脉供血实现的,并且在当前的临床实践中被利用,这被称为化学栓塞或放射栓塞。在我们的研究中,我们开发了负载阿霉素（Dox）的多孔磁性纳米簇（Dox-pMNC）。MNC上的多孔结构和羧基基团实现了高的载药率和持续的药物释放，随着磁特性导致高MRIT2加权图像对比度。碘化油中的Dox-pMNC，Dox-pMNCs，通过肝动脉输注碘化油中的Dox，以靶向兔模型中的肝肿瘤。MRI和组织学评估表明，碘化油中Dox-pMNCs的长期药物释放和保留可引起肝癌细胞死亡。
