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Abstract：
Five medical databases were searched for studies that assessed the role of ERβ in the female cardiovascular system and the influence of age and menopause on ERβ functioning. Of 9472 references, 88 studies met our inclusion criteria (71 animal model experimental studies, 15 human model experimental studies and 2 population based studies). ERβ signaling was shown to possess vasodilator and antiangiogenic properties by regulating the activity of nitric oxide, altering membrane ionic permeability in vascular smooth muscle cells, inhibiting vascular smooth muscle cell migration and proliferation and by regulating adrenergic control of the arteries. Also, a possible protective effect of ERβ signaling against left ventricular hypertrophy and ischemia/reperfusion injury via genomic and non-genomic pathways was suggested in 27 studies. Moreover, 5 studies reported that the vascular effects of ERβ may be vessel specific and may differ by age and menopause status. ERβ seems to possess multiple functions in the female cardiovascular system. Further studies are needed to evaluate whether isoform-selective ERβ-ligands might contribute to cardiovascular disease prevention.
摘要：
搜索了五个医学数据库，以进行评估ERβ在女性心血管系统中的作用以及年龄和绝经对ERβ功能的影响的研究。在9472个参考文献中，88项研究符合我们的纳入标准(71项动物模型实验研究，15项人体模型实验研究和2项基于人群的研究)。通过调节一氧化氮的活性，显示ERβ信号具有血管扩张剂和抗血管生成特性，改变血管平滑肌细胞的膜离子通透性，抑制血管平滑肌细胞迁移和增殖，并通过调节动脉的肾上腺素能控制。此外，27项研究提示ERβ信号传导通过基因组和非基因组途径对左心室肥厚和缺血/再灌注损伤的可能保护作用.此外，5项研究报道,ERβ的血管效应可能是血管特异性的,并且可能因年龄和绝经状态而异。ERβ似乎在女性心血管系统中具有多种功能。需要进一步的研究来评估同工型选择性ERβ配体是否可能有助于心血管疾病的预防。
