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Abstract：
Smooth tubercle bacilli (STB) including \"Mycobacterium canettii\" are members of the Mycobacterium tuberculosis complex (MTBC), which cause non-contagious tuberculosis in human. This group comprises <100 isolates characterized by smooth colonies and cordless organisms. Most STB isolates have been obtained from patients exposed to the Republic of Djibouti but seven isolates, including the three seminal ones obtained by Georges Canetti between 1968 and 1970, were recovered from patients in France, Madagascar, Sub-Sahara East Africa, and French Polynesia. STB form a genetically heterogeneous group of MTBC organisms with large 4.48 ± 0.05 Mb genomes, which may link Mycobacterium kansasii to MTBC organisms. Lack of inter-human transmission suggested a yet unknown environmental reservoir. Clinical data indicate a respiratory tract route of contamination and the digestive tract as an alternative route of contamination. Further epidemiological and clinical studies are warranted to elucidate areas of uncertainty regarding these unusual mycobacteria and the tuberculosis they cause.
摘要：
光滑结核杆菌（STB），包括“Canettii分枝杆菌”是结核分枝杆菌复合体（MTBC）的成员，导致人类非传染性结核病。该组包含<100个以光滑菌落和无绳生物体为特征的分离株。大多数STB分离株是从暴露于吉布提共和国的患者中获得的，但有7株分离株，包括乔治·卡内蒂在1968年至1970年之间获得的三个开创性的研究，是从法国的患者中恢复的，马达加斯加，撒哈拉以南的东非，法属波利尼西亚。STB形成了具有大的4.48±0.05Mb基因组的MTBC生物的遗传异质性组，这可能会将kansasii分枝杆菌与MTBC生物联系起来。缺乏人与人之间的传播表明了一个未知的环境水库。临床数据表明呼吸道污染途径和消化道作为替代污染途径。需要进一步的流行病学和临床研究来阐明这些异常分枝杆菌及其引起的结核病的不确定性领域。
