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Abstract：
OBJECTIVE: Healthy microcirculation is important to maintain the health of tissues and organs, most notably the heart, kidney and retina. Single components of the diet such as salt, lipids and polyphenols may influence microcirculation, but the effects of dietary patterns that are consistent with current dietary guidelines are uncertain. It was hypothesized that compliance to UK dietary guidelines would have a favourable effect on skin capillary density/recruitment compared with a traditional British diet (control diet).
METHODS: A 12-week randomized controlled trial in men and women aged 40-70 years was used to test whether skin microcirculation, measured by skin video-capillaroscopy on the dorsum of the finger, influenced functional capillary density (number of capillaries perfused under basal conditions), structural capillary density (number of anatomical capillaries perfused during finger cuff inflation) and capillary recruitment (percentage difference between structural and functional capillary density).
RESULTS: Microvascular measures were available for 137 subjects out of the 165 participants randomized to treatment. There was evidence of compliance to the dietary intervention, and participants randomized to follow dietary guidelines showed significant falls in resting supine systolic, diastolic and mean arterial pressure of 3.5, 2.6 and 2.9 mmHg compared to the control diet. There was no evidence of differences in capillary density, but capillary recruitment was 3.5 % (95 % CI 0.2, 6.9) greater (P = 0.04) on dietary guidelines compared with control.
CONCLUSIONS: Adherence to dietary guidelines may help maintain a healthy microcirculation in middle-aged men and women. This study is registered at www.isrctn.com as ISRCTN92382106.
METHODS: A 12-week randomized controlled trial in men and women aged 40-70 years was used to test whether skin microcirculation, measured by skin video-capillaroscopy on the dorsum of the finger, influenced functional capillary density (number of capillaries perfused under basal conditions), structural capillary density (number of anatomical capillaries perfused during finger cuff inflation) and capillary recruitment (percentage difference between structural and functional capillary density).
RESULTS: Microvascular measures were available for 137 subjects out of the 165 participants randomized to treatment. There was evidence of compliance to the dietary intervention, and participants randomized to follow dietary guidelines showed significant falls in resting supine systolic, diastolic and mean arterial pressure of 3.5, 2.6 and 2.9 mmHg compared to the control diet. There was no evidence of differences in capillary density, but capillary recruitment was 3.5 % (95 % CI 0.2, 6.9) greater (P = 0.04) on dietary guidelines compared with control.
CONCLUSIONS: Adherence to dietary guidelines may help maintain a healthy microcirculation in middle-aged men and women. This study is registered at www.isrctn.com as ISRCTN92382106.
摘要：
目的：健康的微循环对于维持组织和器官的健康至关重要，最值得注意的是心脏，肾脏和视网膜.饮食中的单一成分，如盐，脂质和多酚可能会影响微循环，但与当前膳食指南一致的膳食模式的效果尚不确定.据推测，与传统的英国饮食（控制饮食）相比，遵守英国饮食指南将对皮肤毛细血管密度/招募产生有利影响。
方法：在40-70岁的男性和女性中进行了为期12周的随机对照试验，以测试皮肤微循环是否，通过手指背部的皮肤视频毛细管镜检查来测量，影响功能性毛细血管密度(在基础条件下灌注的毛细血管数量)，结构毛细血管密度（指套充气过程中灌注的解剖毛细血管数量）和毛细血管募集（结构和功能毛细血管密度之间的百分比差异）。
结果：在165名随机接受治疗的受试者中，137名受试者可进行微血管测量。有证据表明饮食干预的依从性，随机接受饮食指南的参与者显示静息仰卧收缩压明显下降，与对照饮食相比，舒张压和平均动脉压为3.5、2.6和2.9mmHg。没有证据表明毛细血管密度有差异，但与对照组相比,饮食指南的毛细血管募集量增加了3.5%(95%CI0.2,6.9)(P=0.04).
结论：遵守饮食指南可能有助于维持中年男性和女性健康的微循环。本研究在www注册。isrctn.com为ISRCTN92382106。
方法：在40-70岁的男性和女性中进行了为期12周的随机对照试验，以测试皮肤微循环是否，通过手指背部的皮肤视频毛细管镜检查来测量，影响功能性毛细血管密度(在基础条件下灌注的毛细血管数量)，结构毛细血管密度（指套充气过程中灌注的解剖毛细血管数量）和毛细血管募集（结构和功能毛细血管密度之间的百分比差异）。
结果：在165名随机接受治疗的受试者中，137名受试者可进行微血管测量。有证据表明饮食干预的依从性，随机接受饮食指南的参与者显示静息仰卧收缩压明显下降，与对照饮食相比，舒张压和平均动脉压为3.5、2.6和2.9mmHg。没有证据表明毛细血管密度有差异，但与对照组相比,饮食指南的毛细血管募集量增加了3.5%(95%CI0.2,6.9)(P=0.04).
结论：遵守饮食指南可能有助于维持中年男性和女性健康的微循环。本研究在www注册。isrctn.com为ISRCTN92382106。
