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Abstract：
The literature on peristomal pyoderma gangrenosum (PPD) is scarce, and studies to date have included few patients. It is therefore difficult to determine the incidence of PPD, investigate risk factors, or evaluate the effectiveness of the different treatments available. We report on a series of 4 patients diagnosed with PPD at our hospital in 2013 and 2014, and review the clinical characteristics and responses to treatment. Three of the patients had inflammatory bowel disease and 1 had rectal cancer. Three patients responded favorably to initial treatment with 0.1% tacrolimus ointment (administered as monotherapy in 2 cases and combined with immunosuppressants in the other). However, on withdrawal of tacrolimus, the disease recurred in all 3 patients, requiring treatment reintroduction or modification.
摘要：
关于坏疽性脓皮病（PPD）的文献很少，迄今为止的研究包括很少的患者。因此，很难确定PPD的发病率，调查危险因素，或评估不同治疗方法的有效性。我们报告了2013年和2014年在我院诊断为PPD的4例患者，并回顾了其临床特征和对治疗的反应。其中3例患有炎症性肠病，1例患有直肠癌。三名患者对0.1％他克莫司软膏的初始治疗反应良好（2例单药治疗，另一例与免疫抑制剂联合使用）。然而,他克莫司退出后，3名患者都复发了,需要重新引入或修改治疗。
