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Abstract：
Lung cancer is the leading cause of cancer-related mortality worldwide. Diagnosis of lung cancer in an early stage is still a challenge due to the asymptomatic course of early stages of the disease and the lack of a standard screening program for the population. Nowadays, learning about the mechanisms that lead to cancerogenesis in the lung is crucial for the development of new diagnostic and therapeutic strategies. Recently, many studies have proved that cancer stem cells (CSCs) are responsible for the initiation, progression, metastasis, recurrence, and even resistance of chemo- and radiotherapeutic treatment in patients with lung cancer. The expression of pluripotency transcription factors is responsible for stemness properties. In this review, we summarize the current knowledge on the role of CSCs and pluripotency transcription factors in lung carcinogenesis.
摘要：
肺癌是全球癌症相关死亡的主要原因。由于疾病早期阶段的无症状过程以及缺乏针对人群的标准筛查程序，因此早期诊断肺癌仍然是一个挑战。如今,了解导致肺癌发生的机制对于开发新的诊断和治疗策略至关重要.最近,许多研究已经证明，癌症干细胞（CSCs）负责启动，programming,转移,复发,甚至肺癌患者对化疗和放疗的耐药性。多能性转录因子的表达负责干性特性。在这次审查中,我们总结了目前关于CSCs和多能性转录因子在肺癌发生中的作用的知识。
