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Abstract：
Population-based studies have shown an inverse association between dietary menaquinones (MK-n, vitamin K2) intake, coronary calcification and CHD risk, suggesting a potential role of vitamin K in vascular health. To date, the effects of increased menaquinone intake on (markers of) vascular health have been investigated using predominantly food supplements. Dairy products contain many essential nutrients and can serve as a good matrix for food fortification in order to support health. We were therefore interested to study the effects of a menaquinone-fortified yogurt drink (menaquinone as menaquinone-7 (MK-7); 28 µg MK-7/yogurt drink) on vitamin K status and markers of vascular health. The yogurt drink was also fortified with n-3 PUFA, vitamin D, vitamin C, Ca and Mg to support vascular and/or general health. Healthy men (n 32) and postmenopausal women (n 28) with a mean age of 56 (sd 5) years received either basic or fortified yogurt drink twice per d for 12 weeks. MK-7 was efficiently absorbed from the fortified yogurt drink. Levels of circulating MK-7 were significantly increased from 0·28 to 1·94 ng/ml. In accordance, intake of the fortified yogurt drink improved vitamin K status, as measured by significant decreases in uncarboxylated osteocalcin and desphospho-uncarboxylated matrix Gla-protein. No effects were, however, seen on markers of inflammation, endothelial dysfunction and lipid metabolism. In summary, consumption of a yogurt drink fortified with low doses of among others MK-7 for 3 months significantly improved vitamin K status in a healthy population.
摘要：
基于人群的研究表明，膳食甲基萘醌(MK-n，维生素K2）摄入量，冠状动脉钙化和冠心病风险，提示维生素K在血管健康中的潜在作用。迄今为止,已经主要使用食品补充剂研究了增加甲基萘醌摄入量对血管健康（标志物）的影响。乳制品含有许多必需营养素，可以作为食品强化的良好基质，以支持健康。因此，我们有兴趣研究甲基萘醌强化酸奶饮料（甲基萘醌作为甲基萘醌-7（MK-7）；28µgMK-7/酸奶饮料）对维生素K状态和血管健康标志物的影响。酸奶饮料还添加了n-3PUFA，维生素D,维生素C,Ca和Mg支持血管和/或一般健康。平均年龄为56（sd5）岁的健康男性（n32）和绝经后女性（n28）每天接受两次基本或强化酸奶饮料，持续12周。MK-7从强化酸奶饮料中被有效吸收。循环MK-7的水平从0·28显着增加到1·94ng/ml。InAccording,摄入强化酸奶饮料改善维生素K状态，通过非羧化骨钙蛋白和去磷酸-非羧化基质Gla蛋白的显着减少来测量。没有影响，然而,在炎症标记上看到，内皮功能障碍和脂质代谢。总之,在健康人群中，服用低剂量MK-7强化的酸奶饮料3个月可显着改善维生素K状态。
