内源性白细胞介素 - 6 受体 (IL - 6R) 的脱落由去整合素和金属蛋白酶 (ADAM) 蛋白酶控制, 而全长 IL - 6R 同种型定位于循环微泡。
关键词: ADAM ADAM10 ADAM17 exosomes interleukin 6 (IL-6) interleukin 6 receptor (IL6R) microvesicles protease shedding
Mesh : ADAM Proteins / metabolism ADAM10 Protein ADAM17 Protein Amyloid Precursor Protein Secretases / metabolism Animals Cell Line Humans Lipopolysaccharides / pharmacology Membrane Proteins / metabolism Mice Monocytes / drug effects metabolism Protein Isoforms / metabolism Proteolysis RNA Splicing Receptors, Interleukin-6 / genetics metabolism Tetradecanoylphorbol Acetate / pharmacology
来 源:
DOI:10.1074/jbc.M115.649509
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