关键词: African American Afroamericanos Americans Antihipertensivos Antihypertensives for African Epidemiology of hypertension Epidemiología de la hipertensión Hipertensión Hypertension Pathogenesis of hypertension Patogénesis de la hipertensión para afroamericanos

Mesh : African Americans / statistics & numerical data Antihypertensive Agents / therapeutic use Comorbidity Diet, Sodium-Restricted Endothelium, Vascular / physiopathology Exercise Therapy Female Genetic Predisposition to Disease Humans Hypertension / ethnology etiology physiopathology therapy Male Obesity / epidemiology Prevalence Renin-Angiotensin System / physiology Sodium Chloride, Dietary / adverse effects United States / epidemiology

来  源:   DOI:10.1016/j.nefro.2015.05.014   PDF(Sci-hub)

Abstract:
Arterial hypertension is prevalent in the black population in the United States. It is directly related to cardiovascular and kidney damage. Its pathogenesis is complex and includes the high incidence of obesity, salt sensitivity and the activation of the renin-angiotensin-aldosterone system. This complexity requires a therapeutic combination that includes changes in dietary habits and appropriate antihypertensive regimes. The International Society of Hypertension in Blacks recommends initiating dietary intervention for values of systolic/diastolic arterial blood pressure above 115/75 mmHg and maintaining arterial blood pressure below 135/85 mmHg using appropiate antihypertensive medication. The most adequate antihypertensive drug for this population has yet to be determined.
摘要:
动脉高血压在美国的黑人人群中普遍存在。它与心血管和肾脏损害直接相关。其发病机制复杂,包括肥胖的高发,盐敏感性和肾素-血管紧张素-醛固酮系统的激活。这种复杂性需要治疗组合,包括改变饮食习惯和适当的抗高血压方案。国际黑人高血压协会建议使用适当的抗高血压药物对收缩压/舒张压高于115/75mmHg的动脉血压值进行饮食干预,并将动脉血压维持在135/85mmHg以下。尚未确定该人群最适合的抗高血压药物。
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