[Graft-versus-host disease, a rare complication of lung transplantation].

• 发表时间: Feb 2016
• 来源期刊: Rev Pneumol Clin
• DOI: 10.1016/j.pneumo.2015.05.004
• PMID: 26209034
• 文章类型: Case Reports
• 中科院分区: Q4
• 方向: 医学
• 作者列表: Morisse-Pradier H,Nove-Josserand R,Philit F,Senechal A,Berger F,Callet-Bauchu E,Traverse-Glehen A,Maury JM,Grima R,Tronc F,Mornex JF

关键词: Chimerism; Chimérisme; Graft-versus-host disease; Lung transplantation; Maladie du greffon contre l’hôte; Transplantation pulmonaire

Mesh: Adult; Cystic Fibrosis / therapy; Female; Graft vs Host Disease / pathology; Humans; Lung Transplantation / adverse effects; Respiratory Insufficiency / etiology therapy

Abstract

Graft-versus-host disease (GVHD) is a classic and frequent multisystemic complication of bone marrow allografts. It has also been reported after the transplantation of solid organs such as the liver or gut. Recent cases of GVHD have been reported after lung and heart-lung transplant. Skin, liver, gastrointestinal tract and bone marrow are the organ preferentially affected by GVHD. Corticosteroid is the first line treatment of GVHD. The prognosis reported in solid organ transplants is poor with infectious complications favoured by immunosuppressive therapy. In this article, we report a case of a patient with cystic fibrosis who presented a probable GVHD 18 months after a lung transplant and a literature review of similar cases.