关键词: ACT, adoptive cell therapy Ag, antigen CAR, chimeric antigen receptor CD4+ CTL CTL, cytotoxic T lymphocyte DC, dendritic cell GzmB, granzyme B IL-12 IL-12, interleukin-12 NKT NKT, natural killer T cell ThPOK cytokine therapy cytotoxicity immunotherapy

来  源:   DOI:10.4161/2162402X.2014.994370   PDF(Sci-hub)

Abstract:
CD4+ T cells represent an entire arm of the immune system that has hitherto been incompletely understood, but their potential to act as both helper and effector may make them optimal protagonists in immunotherapeutic approaches to treat cancer. Cytokine therapy can activate this population in a manner that ensures maximal diversification of effector function for a robust immune response.
摘要:
CD4+T细胞代表了迄今为止尚未完全了解的整个免疫系统,但是它们作为辅助和效应物的潜力可能使它们成为治疗癌症的免疫治疗方法中的最佳激动剂。细胞因子疗法可以以确保效应子功能的最大多样化的方式激活该群体,以实现稳健的免疫应答。
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