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Abstract：
BACKGROUND: Hysteroscopy is an indispensable approach in gynecology. Miniaturization may reduce pain allowing office procedures without anesthesia.
OBJECTIVE: Our main objective is to determine if modifications in scope diameters have made office hysteroscopy less painful.
METHODS: Studies were sought with key words \"hysteroscopy\" and \"pain\" from available online sources. Time frame was from 2000 onward. Thirty-three articles were retrieved for detailed analysis.
METHODS: Prospective randomized trials, studying pain as main outcome in office hysteroscopy expressed in means, confidence intervals and SD, comparing office mini-hysteroscopy to conventional hysteroscopy. Studies or arms within a study where conscientious sedation, anesthesia or non-steroidal drugs were used were excluded.
METHODS: We analyzed data from eight studies (seven RCT) comparing mini-hysteroscopy with conventional scopes, involving a total of twenty-three hundred and twenty-two participants, of which nineteen hundred and eighty-six completed the intervention.
RESULTS: A meta-analysis revealed a significant reduction pain score (MD: -3.64; 95 % CI -5.16 to -2.12; test for overall effect p < 0.00001) and available data support miniaturization decreases pain in outpatient hysteroscopy.
CONCLUSIONS: Pain in office hysteroscopy is lower with mini-hysteroscopes.
OBJECTIVE: Our main objective is to determine if modifications in scope diameters have made office hysteroscopy less painful.
METHODS: Studies were sought with key words \"hysteroscopy\" and \"pain\" from available online sources. Time frame was from 2000 onward. Thirty-three articles were retrieved for detailed analysis.
METHODS: Prospective randomized trials, studying pain as main outcome in office hysteroscopy expressed in means, confidence intervals and SD, comparing office mini-hysteroscopy to conventional hysteroscopy. Studies or arms within a study where conscientious sedation, anesthesia or non-steroidal drugs were used were excluded.
METHODS: We analyzed data from eight studies (seven RCT) comparing mini-hysteroscopy with conventional scopes, involving a total of twenty-three hundred and twenty-two participants, of which nineteen hundred and eighty-six completed the intervention.
RESULTS: A meta-analysis revealed a significant reduction pain score (MD: -3.64; 95 % CI -5.16 to -2.12; test for overall effect p < 0.00001) and available data support miniaturization decreases pain in outpatient hysteroscopy.
CONCLUSIONS: Pain in office hysteroscopy is lower with mini-hysteroscopes.
摘要：
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