腺病毒载体通用流感疫苗的研究进展。
关键词: ADCC, antibody-dependent cell-mediated cytotoxicity APC, antigen-presenting cell Ad: adenovirus CAR, Coxsackie-Adenovirus Receptor CTLs, cytotoxic T lymphocytes DC, lung dendritic cells DVD, drug–vaccine duo FcγRs, Fc receptors for IgG HA, hemagglutinin HDAd, helper-dependent adenoviral HEK293, human embryonic kidney 293 cell HI, hemagglutination inhibition HLA, human leukocyte antigen IF-γ, interferon-γ IFV, Influenza virus IIVV, inactivated influenza virus vaccine IL-2, interleukin-2 ITRs, inverted terminal repeats LAIV, live attenuated influenza vaccine M1, matrix protein 1 M2, matrix protein 2 MHC-I, major histocompatibility complex class I NA, neuraminidase NP, nucleoprotein RCA, replication competent adenovirus VAERD, vaccine-associated enhanced respiratory disease adenovirus vector broadly neutralizing antibodies cellular immunity flu, influenza hemagglutinin humoral immunity influenza mAbs, monoclonal antibodies mucosal immunity rAd, recombinant adenovirus universal vaccine
Mesh : Adenoviridae / genetics Animals Drug Carriers Drug Discovery / trends Genetic Vectors Hemagglutinin Glycoproteins, Influenza Virus / genetics immunology Humans Influenza Vaccines / genetics immunology Nucleocapsid Proteins Orthomyxoviridae / genetics immunology RNA-Binding Proteins / genetics immunology Vaccines, Synthetic / genetics immunology Viral Core Proteins / genetics immunology Viral Matrix Proteins / genetics immunology
来 源: DOI:10.1080/21645515.2015.1016674 PDF(Sci-hub)