血细胞和内皮屏障功能。
关键词: AJ, Adherens junctions ANG-1, Angiopoietin 1 AQP, Aquaporins BBB, blood brain barrier CNS, Central nervous system COPD, Chronic obstructive pulmonary disease EAE, Experimental autoimmune encephalomyelitis EPAC1, Exchange protein activated by cyclic AMP ERK1/2, Extracellular signal-regulated kinases 1 and 2 Endothelial barrier FA, Focal adhesions FAK, focal adhesion tyrosine kinase FoxO1, Forkhead box O1 GAG, Glycosaminoglycans GDNF, Glial cell-derived neurotrophic factor GJ, Gap junctions GPCR, G-protein coupled receptors GTPase, Guanosine 5'-triphosphatase HMGB-1, High mobility group box 1 HRAS, Harvey rat sarcoma viral oncogene homolog ICAM-1, Intercellular adhesion molecule 1 IL-1β, Interleukin 1 beta IP3, Inositol 1,4,5-triphosphate JAM, Junctional adhesion molecules MEK, Mitogen-activated protein kinase kinase MLC, Myosin light chain MLCK, Myosin light-chain kinase MMP, Matrix metalloproteinases NO, Nitric oxide OSM, Oncostatin M PAF, Platelet activating factor PDE, Phosphodiesterase PKA, Protein kinase A PNA, Platelet-neutrophil aggregates ROS, Reactive oxygen species Rac1, Ras-related C3 botulinum toxin substrate 1 Rap1, Ras-related protein 1 RhoA, Ras homolog gene family, member A S1P, Sphingosine-1-phosphate SCID, Severe combined immunodeficient SOCS-3, Suppressors of cytokine signaling 3 Shp-2, Src homology 2 domain-containing phosphatase 2 Src, Sarcoma family of protein kinases TEER, Transendothelial electrical resistance TGF-beta1, Transforming growth factor-beta1 TJ, Tight junctions TNF-, Tumor necrosis factor alpha VCAM-1, Vascular cell adhesion molecule 1 VE, Vascular endothelial VE-PTP, Vascular endothelial receptor protein tyrosine phosphatase VEGF, Vascular endothelial growth factor VVO, Vesiculo-vacuolar organelle ZO, Zonula occludens cAMP, 3'-5'-cyclic adenosine monophosphate erythrocytes leukocytes pSrc, Phosphorylated Src platelets vascular permeability
来 源:
DOI:10.4161/21688370.2014.978720
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