PDF(Pubmed)
Abstract：
Male genital lichen sclerosus (MGLSc) is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. An afeared complication is squamous cell carcinoma (SCC) of the penis. The precise etiopathogenesis of MGLSc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (HPV) hepatitis C (HCV), Epstein-Barr virus (EBV) and Borrelia) factors have been implicated: Consideration of all the evidence suggests that chronic exposure of susceptible epithelium to urinary occlusion by the foreskin seems the most likely pathomechanism. The mainstay of treatment is topical ultrapotent corticosteroid therapy. Surgery is indicated for cases unresponsive to topical corticosteroid therapy, phimosis, meatal stenosis, urethral stricture, carcinoma in situ (CIS) and squamous cell carcinoma.
摘要：
男性生殖器硬化性苔藓（MGLSc）是一种慢性炎症性皮肤病，可导致男性性交困难和泌尿外科发病。一种古老的并发症是阴茎鳞状细胞癌（SCC）。MGLSc的确切病因仍存在争议，尽管遗传，自身免疫性和感染性（如人乳头瘤病毒（HPV）丙型肝炎（HCV），涉及爱泼斯坦-巴尔病毒（EBV）和疏螺旋体）因素：考虑所有证据表明，易感上皮长期暴露于包皮的尿路阻塞似乎是最可能的病理机制。治疗的主要方法是局部超效皮质类固醇治疗。手术适用于对局部皮质类固醇治疗无反应的病例。包茎,肉孔狭窄,尿道狭窄,原位癌（CIS）和鳞状细胞癌。
