Abstract：
Demineralized bone matrix has been successfully commercialized as an alternative bone graft material that not only can function as filler but also as an osteoinductive graft. Numerous studies have confirmed its beneficial use in clinical practice. Heterotopic ossification after internal fixation combined with the use of demineralized bone matrix has not been widely reported. In this paper we describe a 39 year old male who sustained a complex articular fracture that developed clinically significant heterotopic ossification after internal fixation with added demineralized bone matrix. Although we cannot be sure that there is a cause-and-effect relation between demineralized bone matrix and the excessive heterotopic ossification seen in our patient, it seems that some caution in using demineralised bone matrix in similar cases is warranted. Also, given the known inter- and intraproduct variability, the risks and benefits of these products should be carefully weighed.
摘要：
脱矿质骨基质已经成功地商业化作为替代骨移植材料,其不仅可以用作填充剂而且还可以用作骨诱导移植物。许多研究已经证实其在临床实践中的有益用途。内固定结合脱钙骨基质使用后的异位骨化尚未得到广泛报道。在本文中，我们描述了一名39岁的男性，他患有复杂的关节骨折，在添加了去矿质骨基质的内固定后，发生了临床上明显的异位骨化。尽管我们不能确定脱矿骨基质与我们患者的过度异位骨化之间存在因果关系，在类似病例中使用去矿质骨基质似乎需要谨慎。此外，鉴于已知的产品间和产品内变异性，这些产品的风险和好处应该仔细权衡。
