Mesh : Antipsychotic Agents / administration & dosage Chlorpromazine / administration & dosage Dose-Response Relationship, Drug Humans Psychotic Disorders / drug therapy Therapeutic Equivalency

来  源:   DOI:10.1097/00004850-198904000-00001   PDF(Sci-hub)

Abstract:
Chlorpromazine (CPZ) equivalents are often used as a relative measure of the antipsychotic potency of neuroleptics. We review the CPZ equivalents of 33 neuroleptics and illustrate why imprecisions or discrepancies will be difficult to eliminate from these values. We nevertheless underline that CPZ equivalents can be clinically useful, since they facilitate the choice of doses of different neuroleptics that should induce comparable antipsychotic effects.
摘要:
氯丙嗪(CPZ)当量通常用作抗精神病药的抗精神病药效的相对量度。我们回顾了33种精神抑制药的CPZ等价物,并说明了为什么很难从这些值中消除不精确或差异。尽管如此,我们强调CPZ等效物可以在临床上有用,因为它们有助于选择不同抗精神病药的剂量,这些抗精神病药应该引起可比的抗精神病药作用。
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