Mesh : Administration, Oral Antipsychotic Agents / administration & dosage Chlorpromazine / administration & dosage Delayed-Action Preparations Dose-Response Relationship, Drug Humans Psychotic Disorders / drug therapy Therapeutic Equivalency

来  源:   DOI:10.1097/00004850-198904000-00002   PDF(Sci-hub)

Abstract:
When changing from daily oral to long acting injectable neuroleptic therapy, it is essential to choose a dose that will maintain clinical efficacy without increased adverse reactions. Information on pharmacokinetics is needed to achieve this. The authors present guidelines based on this information and observe that previous recommendations sometimes differ substantially from these guidelines. Whether these guidelines will improve the results of long term treatment of psychotic patients remains to be determined.
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