OBJECTIVE: We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p\'-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin-like polychlorinated biphenyl congener 153 (PCB-153).
METHODS: We evaluated 576 men with newly diagnosed PCa (before treatment) and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case-control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation.
RESULTS: We estimated a significant positive association between DDE and PCa [adjusted odds ratio (OR) = 1.53; 95% CI: 1.02, 2.30 for the highest vs. lowest quintile of exposure; p trend = 0.01]. PCB-153 was inversely associated with PCa (OR = 0.30; 95% CI: 0.19, 0.47 for the highest vs. lowest quintile of exposure values; p trend < 0.001). Also, PCB-153 was more strongly associated with low-grade than with high-grade PCa.
CONCLUSIONS: Associations of PCa with DDE and PCB-153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs; and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health.
目的:我们研究了PCa与普遍分布的污染物的血浆浓度之间的关系,特别是p,对二氯二苯基二氯乙烯(DDE)和非二恶英样多氯联苯同类物153(PCB-153)。
方法:我们在瓜德罗普岛(法属西印度群岛)评估了576例新诊断为PCa的男性(治疗前)和655例对照。根据病例对照状态分析暴露情况。通过无条件逻辑回归分析评估关联,控制混杂因素。缺少的数据通过多重插补处理。
结果:我们估计DDE和PCa之间存在显著正相关[调整后比值比(OR)=1.53;95%CI:1.02,2.30最低五分之一的暴露;p趋势=0.01]。PCB-153与PCa呈负相关(OR=0.30;95%CI:0.19,0.47,最高暴露值的最低五分之一;p趋势<0.001)。此外,PCB-153与低级PCa的相关性比与高级PCa的相关性更强。
结论:PCa与DDE和PCB-153的关联方向相反。这可能反映了这些EDC作用机制的差异;尽管我们的发现需要在其他人群中复制,它们与EDC对人类健康的复杂影响一致。