PDF(Pubmed)
Abstract：
BACKGROUND: Long-term exposure to persistent pollutants with hormonal properties (endocrine-disrupting chemicals; EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited.
OBJECTIVE: We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p\'-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin-like polychlorinated biphenyl congener 153 (PCB-153).
METHODS: We evaluated 576 men with newly diagnosed PCa (before treatment) and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case-control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation.
RESULTS: We estimated a significant positive association between DDE and PCa [adjusted odds ratio (OR) = 1.53; 95% CI: 1.02, 2.30 for the highest vs. lowest quintile of exposure; p trend = 0.01]. PCB-153 was inversely associated with PCa (OR = 0.30; 95% CI: 0.19, 0.47 for the highest vs. lowest quintile of exposure values; p trend < 0.001). Also, PCB-153 was more strongly associated with low-grade than with high-grade PCa.
CONCLUSIONS: Associations of PCa with DDE and PCB-153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs; and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health.
OBJECTIVE: We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p\'-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin-like polychlorinated biphenyl congener 153 (PCB-153).
METHODS: We evaluated 576 men with newly diagnosed PCa (before treatment) and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case-control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation.
RESULTS: We estimated a significant positive association between DDE and PCa [adjusted odds ratio (OR) = 1.53; 95% CI: 1.02, 2.30 for the highest vs. lowest quintile of exposure; p trend = 0.01]. PCB-153 was inversely associated with PCa (OR = 0.30; 95% CI: 0.19, 0.47 for the highest vs. lowest quintile of exposure values; p trend < 0.001). Also, PCB-153 was more strongly associated with low-grade than with high-grade PCa.
CONCLUSIONS: Associations of PCa with DDE and PCB-153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs; and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health.
摘要：
背景：长期暴露于具有激素特性的持久性污染物（内分泌干扰化学物质；EDC）可能会导致前列腺癌（PCa）的风险。然而,流行病学证据仍然有限。
目的：我们研究了PCa与普遍分布的污染物的血浆浓度之间的关系，特别是p,对二氯二苯基二氯乙烯（DDE）和非二恶英样多氯联苯同类物153（PCB-153）。
方法：我们在瓜德罗普岛（法属西印度群岛）评估了576例新诊断为PCa的男性（治疗前）和655例对照。根据病例对照状态分析暴露情况。通过无条件逻辑回归分析评估关联，控制混杂因素。缺少的数据通过多重插补处理。
结果：我们估计DDE和PCa之间存在显著正相关[调整后比值比（OR）=1.53；95%CI：1.02，2.30最低五分之一的暴露；p趋势=0.01]。PCB-153与PCa呈负相关（OR=0.30；95%CI：0.19，0.47，最高暴露值的最低五分之一；p趋势<0.001)。此外，PCB-153与低级PCa的相关性比与高级PCa的相关性更强。
结论：PCa与DDE和PCB-153的关联方向相反。这可能反映了这些EDC作用机制的差异；尽管我们的发现需要在其他人群中复制，它们与EDC对人类健康的复杂影响一致。
目的：我们研究了PCa与普遍分布的污染物的血浆浓度之间的关系，特别是p,对二氯二苯基二氯乙烯（DDE）和非二恶英样多氯联苯同类物153（PCB-153）。
方法：我们在瓜德罗普岛（法属西印度群岛）评估了576例新诊断为PCa的男性（治疗前）和655例对照。根据病例对照状态分析暴露情况。通过无条件逻辑回归分析评估关联，控制混杂因素。缺少的数据通过多重插补处理。
结果：我们估计DDE和PCa之间存在显著正相关[调整后比值比（OR）=1.53；95%CI：1.02，2.30最低五分之一的暴露；p趋势=0.01]。PCB-153与PCa呈负相关（OR=0.30；95%CI：0.19，0.47，最高暴露值的最低五分之一；p趋势<0.001)。此外，PCB-153与低级PCa的相关性比与高级PCa的相关性更强。
结论：PCa与DDE和PCB-153的关联方向相反。这可能反映了这些EDC作用机制的差异；尽管我们的发现需要在其他人群中复制，它们与EDC对人类健康的复杂影响一致。
