鉴定控制轴突存活因子烟酰胺单核苷酸腺苷酰转移酶 2 ( NMNAT2 ) 亚细胞定位的棕榈酰转移酶和硫酯酶。
关键词: APT1 APT2 Enzyme Intracellular Trafficking NMNAT2 Neurodegeneration Palmitoyltransferase Protein Acylation Protein Palmitoylation zDHHC17
Mesh : Acyltransferases / genetics metabolism Animals Axons / metabolism Blotting, Western Cell Membrane / metabolism Cells, Cultured HEK293 Cells Humans Lipoylation / drug effects Mice, Inbred C57BL Mutation Neurons / cytology drug effects metabolism Nicotinamide-Nucleotide Adenylyltransferase / genetics metabolism Palmitic Acid / metabolism Propiolactone / analogs & derivatives pharmacology RNA Interference Reverse Transcriptase Polymerase Chain Reaction Substrate Specificity Thiolester Hydrolases / genetics metabolism
来 源:
DOI:10.1074/jbc.M114.582338
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