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Abstract：
Systemic AA amyloidosis is a serious complication of many chronic inflammatory disorders and chronic infections. Renal involvement is seen in the majority of the patients and can lead to end-stage renal disease. Renal transplantation can be performed in these patients; however, amyloidosis can recur in the transplanted kidneys. On the other hand, de novo AA amyloidosis in renal transplant patients has been rarely reported. We report a 17-yr-old patient with end-stage renal disease due to genitourinary anomalies who developed recurrent pyelonephritis after transplantation. Three yr after transplantation, renal biopsy was performed for proteinuria and AA amyloidosis was identified in the renal allograft. Although rare, chronic infections might cause de novo amyloidosis in renal transplant patients. Therefore, amyloidosis should be kept in mind in those types of patients who present with proteinuria.
摘要：
全身性AA淀粉样变性是许多慢性炎症性疾病和慢性感染的严重并发症。在大多数患者中可见肾脏受累，并可导致终末期肾脏疾病。这些患者可以进行肾移植;然而，淀粉样变性可以在移植的肾脏中复发。另一方面,肾移植患者的从头AA淀粉样变性很少报道。我们报告了一名17岁的因泌尿生殖系统异常而患有终末期肾病的患者，该患者在移植后发生复发性肾盂肾炎。移植后三年，对蛋白尿进行了肾活检，并在同种异体肾移植中发现了AA淀粉样变性。虽然罕见，慢性感染可能导致肾移植患者的新生淀粉样变性。因此,在出现蛋白尿的患者中，应牢记淀粉样变性。
