METHODS: We conducted a single-blinded, two-armed, randomized controlled trial with 12-month follow-up.
METHODS: The study was conducted in St Petersburg, Russia. Participants were recruited from four HIV and addiction clinical sites. The intervention was conducted at Botkin Infectious Disease Hospital.
METHODS: HIV-infected individuals with past 6-month risky sex and heavy alcohol consumption (n = 700) were randomized to the HERMITAGE intervention (n = 350) or an attention control condition (n = 350).
METHODS: A Healthy Relationships Intervention stressing disclosure of HIV serostatus and condom use, adapted for a Russian clinical setting with two individual sessions and three small group sessions.
METHODS: The primary outcome was incident STI by laboratory test at 12-month follow-up. Secondary outcomes included change in unprotected sex and several alcohol and injection drug use (IDU) variables.
RESULTS: Participants had the following baseline characteristics: 59.3% male, mean age 30.1, 60.4% past year IDU, 15.4% prevalent STI and mean CD4 cell count 413.3/μl. Assessment occurred among 75 and 71% of participants at 6 and 12 months, respectively. STIs occurred in 20 subjects (8.1%) in the intervention group and 28 subjects (12.0%) in the control group at 12-month follow-up; logistic regression analyses found no significant difference between groups (adjusted odds ratio 0.63; 95% confidence interval = 0.34-1.18; P = 0.15). Both groups decreased unsafe behaviors, although no significant differences were found between groups.
CONCLUSIONS: The HERMITAGE HIV risk reduction intervention does not appear to reduce sexually transmitted infections and HIV risk behaviors in Russian HIV-infected heavy drinkers compared with attention controls.
方法:我们进行了单盲,双臂,12个月随访的随机对照试验。
方法:这项研究在圣彼得堡进行,俄罗斯。参与者来自四个HIV和成瘾临床站点。干预在Botkin传染病医院进行。
方法:过去6个月危险性行为和大量饮酒的HIV感染者(n=700)被随机分配到HERMITAGE干预(n=350)或注意控制条件(n=350)。
方法:健康关系干预强调披露艾滋病毒血清状况和使用避孕套,适应俄罗斯的临床环境,有两个单独的会议和三个小组会议。
方法:主要结果是12个月随访时实验室检测的性传播感染。次要结果包括无保护性行为的变化以及一些酒精和注射药物使用(IDU)变量。
结果:参与者具有以下基线特征:59.3%的男性,平均年龄30.1岁,去年IDU为60.4%,15.4%普遍STI和平均CD4细胞计数413.3/μl。在6个月和12个月时,75%和71%的参与者进行了评估。分别。在12个月的随访中,干预组的20名受试者(8.1%)和对照组的28名受试者(12.0%)发生了性传播感染;逻辑回归分析发现两组之间没有显着差异(调整后的比值比0.63;95%置信区间=0.34-1.18;P=0.15)。两组都减少了不安全行为,尽管组间没有发现显著差异。
结论:与注意对照组相比,在俄罗斯感染HIV的重度饮酒者中,HERMITAGEHIV风险降低干预似乎并未减少性传播感染和HIV风险行为。