Abstract：
Two variants of focal segmental glomerulosclerosis are known to present epithelial hypercellularity in the Bowman\'s space, namely the collapsing and the cellular types. This epithelial cell proliferation may get features of either pseudocrescent or tubular profiles. Our case of collapsing focal segmental glomerulosclerosis has been ultrastructurally investigated concerning the proliferating epithelial cell type: parietal versus visceral. Based on the cellular organelles, especially on the ubiquitous presence of desmosomes, the authors are endorsing, with ultrastructural arguments, the opinion favoring the parietal epithelial cells (PEC) as the proliferating cell type. It is also taken into consideration the eventual change of PECs phenotype in contact with the glomerular tuft components like the glomerular basement membrane.
摘要：
已知局灶性节段肾小球硬化的两种变体在Bowman's空间中表现出上皮细胞过多，即塌陷和细胞类型。这种上皮细胞增殖可能具有假新月或管状轮廓的特征。我们的局灶性节段性肾小球硬化塌陷病例已进行了超微结构研究，涉及增殖的上皮细胞类型：顶叶与内脏。基于细胞器，特别是在桥粒无处不在的情况下，作者支持，用超微结构的论点，支持壁上皮细胞（PEC）作为增殖细胞类型的观点。还考虑到PECs表型与肾小球毛簇成分如肾小球基底膜接触的最终变化。
