Abstract：
Based on recommendations of the ECIL-4, we prospectively evaluated discontinuation of empirical antibiotic therapy in high-risk neutropenic acute myeloid leukaemia patients with fever of unknown origin. Seven patients (median neutropenia duration 30 days) were included. Four of them remained afebrile but quickly recovered from neutropenia. The other three had rapid recurrent fever. Two of these three patients had bacteraemia with susceptible strains and one of them was transferred to the ICU for septic shock. Median duration of sparing of antibiotics for the seven patients was 3 days (2-4). Because of these limited results the study was stopped.
摘要：
根据ECIL-4的建议，我们前瞻性地评估了不明原因发热的高危中性粒细胞减少性急性髓系白血病患者停用经验性抗生素治疗的情况。包括7名患者（中性粒细胞减少症持续时间为30天）。其中四人仍保持无热，但很快从中性粒细胞减少症中恢复过来。其他三个人反复发烧。这三名患者中有两名患有易感菌株的菌血症，其中一名因感染性休克被转移到ICU。7名患者的抗生素保留的中位持续时间为3天(2-4)。由于这些有限的结果，该研究停止了。
