肌营养不良蛋白的机械和非机械功能可以预防果蝇的心脏异常。
关键词: AAV AI Adeno-associated virus Aging Arrhythmia index BMD Becker muscular dystrophy CR CT Carboxy-terminal domain Cysteine-rich domain DCM DGC DMD Dbr Dg Dilated cardiomyopathy Duchene muscular dystrophy Dys Dystrobrevin Dystroglycan Dystrophin Dystrophin-glycoprotein complex Endothelial Nos Grb2 Growth factor receptor-bound protein 2 HPs Heart period Heart periods Inducible Nos Micro-Dystrophins Myofibrils NO Neuronal nitric oxide synthase Nitric oxide Nitric oxide synthase SR Sarcoplasmic reticulum Syn Syntrophin Utrn Utrophin X-linked dilated cardiomyopathy XLDCM eNos iNos nNos
Mesh : Aging / genetics physiology Animals Animals, Genetically Modified Cardiomyopathy, Dilated / genetics metabolism prevention & control Drosophila / genetics metabolism Dystroglycans / physiology Dystrophin / deficiency genetics physiology Genetic Therapy / methods Mutation Myocytes, Cardiac / metabolism Nitric Oxide Synthase / metabolism physiology Signal Transduction / physiology
来 源:
DOI:10.1016/j.exger.2013.10.015
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