METHODS: The information was collected from scientific journals, books, and pharmacopeia. The studies about the traditional uses, randomized controlled trials, chemical, pharmacological and pharmacokinetic data related to liquorice-herb/drug interaction or combination were included in the review.
RESULTS: According to recent reports, the \"guide\" effect of liquorice is partially through components transformed in liquorice-drug interaction; altering enzyme activity of P450 isoforms, as evidenced by induction of model probe substrates; and modulation of drug transporter proteins such as intestinal P-glycoprotein.
CONCLUSIONS: The overview and comparison of traditional uses of liquorice with recent pharmacological studies and randomized controlled trials provide new insights into this ancient drug for future investigations and clinical use, especially in drug combination.
方法:这些信息来自科学期刊,书籍,还有药典.关于传统用途的研究,随机对照试验,化学,本综述包括与甘草/药物相互作用或联合用药相关的药理学和药代动力学数据.
结果:根据最近的报道,甘草的“指导”作用部分是通过甘草-药物相互作用中转化的成分;改变P450亚型的酶活性,如模型探针底物的诱导;和药物转运蛋白如肠P-糖蛋白的调节所证明的。
结论:对甘草的传统使用与最近的药理学研究和随机对照试验的概述和比较为这种古老的药物的未来研究和临床使用提供了新的见解,特别是在药物组合中。