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Abstract：
BACKGROUND: Liquorice is the root of Glycyrrhiza uralensis Fisch. or Glycyrrhiza glabra L., Leguminosae. It is a widely used herbal medicine native to southern Europe and parts of Asia and has beneficial applications in both the medicinal and the confectionery sectors. Unlike its usage in Europe, liquorice in traditional Chinese medicine is commonly combined with other herbs in a single prescription, as a unique \"guide drug\" to enhance the effectiveness of other ingredients, to reduce toxicity, and to improve flavor in almost half of Chinese herbal formulas. A review on phytochemical and pharmacological research to explain this unique \"guide\" effect is suggested for future investigations.
METHODS: The information was collected from scientific journals, books, and pharmacopeia. The studies about the traditional uses, randomized controlled trials, chemical, pharmacological and pharmacokinetic data related to liquorice-herb/drug interaction or combination were included in the review.
RESULTS: According to recent reports, the \"guide\" effect of liquorice is partially through components transformed in liquorice-drug interaction; altering enzyme activity of P450 isoforms, as evidenced by induction of model probe substrates; and modulation of drug transporter proteins such as intestinal P-glycoprotein.
CONCLUSIONS: The overview and comparison of traditional uses of liquorice with recent pharmacological studies and randomized controlled trials provide new insights into this ancient drug for future investigations and clinical use, especially in drug combination.
METHODS: The information was collected from scientific journals, books, and pharmacopeia. The studies about the traditional uses, randomized controlled trials, chemical, pharmacological and pharmacokinetic data related to liquorice-herb/drug interaction or combination were included in the review.
RESULTS: According to recent reports, the \"guide\" effect of liquorice is partially through components transformed in liquorice-drug interaction; altering enzyme activity of P450 isoforms, as evidenced by induction of model probe substrates; and modulation of drug transporter proteins such as intestinal P-glycoprotein.
CONCLUSIONS: The overview and comparison of traditional uses of liquorice with recent pharmacological studies and randomized controlled trials provide new insights into this ancient drug for future investigations and clinical use, especially in drug combination.
摘要：
背景：甘草是甘草的根。或甘草，豆科植物.它是一种广泛使用的草药，原产于南欧和亚洲部分地区，在医药和糖果领域都有有益的应用。与它在欧洲的使用不同，传统中药中的甘草通常与其他草药联合在一个处方中，作为一种独特的“指导药物”，以增强其他成分的有效性，为了减少毒性，并改善近一半中草药配方的风味。建议对植物化学和药理学研究进行综述，以解释这种独特的“指南”作用，以供将来进行研究。
方法：这些信息来自科学期刊，书籍,还有药典.关于传统用途的研究，随机对照试验，化学,本综述包括与甘草/药物相互作用或联合用药相关的药理学和药代动力学数据.
结果：根据最近的报道，甘草的“指导”作用部分是通过甘草-药物相互作用中转化的成分；改变P450亚型的酶活性，如模型探针底物的诱导;和药物转运蛋白如肠P-糖蛋白的调节所证明的。
结论：对甘草的传统使用与最近的药理学研究和随机对照试验的概述和比较为这种古老的药物的未来研究和临床使用提供了新的见解，特别是在药物组合中。
方法：这些信息来自科学期刊，书籍,还有药典.关于传统用途的研究，随机对照试验，化学,本综述包括与甘草/药物相互作用或联合用药相关的药理学和药代动力学数据.
结果：根据最近的报道，甘草的“指导”作用部分是通过甘草-药物相互作用中转化的成分；改变P450亚型的酶活性，如模型探针底物的诱导;和药物转运蛋白如肠P-糖蛋白的调节所证明的。
结论：对甘草的传统使用与最近的药理学研究和随机对照试验的概述和比较为这种古老的药物的未来研究和临床使用提供了新的见解，特别是在药物组合中。
