关键词: 5-aminoimidazole-4-carboxamide ribonucleotide ADAM AICAR AKT ALL AML AMPK ANK B-cell chronic lymphocytic leukemia B-precursor acute lymphoblastic leukemia BAD BCL-2 associated death promoter BCL-2 homology domain 3 (BH3)-only protein, B-cell lymphoma 2 interacting mediator of cell death BP-ALL Bim CAMKKβ CBF1/Su(H)/Lag-1 CDK8 CK2 CLL CSL DSL Delta-like Delta–Serrate–Lag1 Dll EFS EGF ERK F-box/WD-repeat containing protein 7 FBW7 FOXO GSC GSI GSK3 HD Hes1 ICN1 IGF1R IGFBP3 IL7Rα IRS1 JME Jag Jagged LKB1 LNR Leukemia Lin12/Notch1 repeats MAML1 MAPK MCL1 MDM2 NEC NTM Notch1 Notch1 extracellular domain Notch1 transmembrane domain PDK1 PEST PI3K PIP(2) PIP(3) PKCθ PP2A PRAS40 PTEN Pro, Glu, Ser, and Thr-rich domain Protein phosphatase 2A ROS RUNX1 and RUNX3 Ser/Thr-protein phosphatase 2A T-ALL T-cell acute lymphoblastic leukemia TACE TAN1 a disintegrin and metalloprotease acute lymphoblastic leukemia acute myeloid leukemia adenosine monophosphate (AMP) activated protein kinase ankyrin-like repeats calmodulin-dependent protein kinase kinase beta casein kinase 2 cyclin-dependent kinase 8 eIF2A and eIF4E epidermal growth factor eukaryotic translation initiating factors 2A and 4E event free survival extracellular signal-regulated protein kinase fork head box O transcription factors glycogen synthase kinase 3 hairy and enhancer of split-1 heterodimerization domain induced myeloid leukemia cell differentiation protein insulin receptor substrate 1 insulin-like growth factor 1 receptor insulin-like growth factor-binding protein 3 interleukin-7 receptor subunit α intracellular domain of Notch1 juxtamembrane expansion liver kinase B1 mSIN1 mTOR mammalian stress-activated protein kinase interacting protein 1 mammalian target of rapamycin mastermind-like protein 1 miR/miRNA micro-RNA mitogen activate protein kinases mouse double minute 2 homolog phosphatase and tensin homolog deleted on chromosome ten phosphatidylinositide 3-kinase phosphatidylinositol (3,4,5)-trisphosphate phosphatidylinositol (4,5)-bisphosphate phosphoinositide dependent protein kinase-1 proline-rich AKT substrate 40kDa protein kinase B (PKB) protein kinase C theta rapamycin-insensitive companion of mTOR raptor reactive oxygen species regulatory-associated protein of mTOR rictor runt-related transcription factors 1 and 3 translocation associated Notch1 homolog tumor necrosis factor α-converting enzyme γ-Secretase inhibitor resistance γ-secretase complex γ-secretase complex inhibitors
Mesh : Amyloid Precursor Protein Secretases / antagonists & inhibitors metabolism Animals Drug Resistance, Neoplasm / drug effects Enzyme Inhibitors / pharmacology therapeutic use Humans Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy enzymology pathology Receptors, Notch / metabolism Signal Transduction / drug effects
来 源:
DOI:10.1016/j.cellsig.2013.09.021
PDF(Sci-hub)