关键词: 9p21 CDKN2A CDKN2B CDKN2B-AS1.

Mesh : Chromosomes, Human, Pair 9 / genetics Cyclin-Dependent Kinase Inhibitor p15 / genetics Cyclin-Dependent Kinase Inhibitor p16 / genetics Genetic Predisposition to Disease Genome-Wide Association Study Genotype Glaucoma, Open-Angle / genetics Humans Intraocular Pressure RNA, Long Noncoding / genetics Risk Factors

来  源:   DOI:10.1111/ceo.12234

Abstract:
Primary open-angle glaucoma (POAG) is a genetically complex disease. Genome-wide association study (GWAS) is a particularly useful tool in the search for genetic contributions to glaucoma. Recently, chromosome 9p21 has become a major focus of research endeavour, with multiple genome-wide association studies suggesting associations to POAG. Herein, we provide a review of the chromosome 9p21 susceptibility locus as a risk factor for POAG.
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