关键词: ARONJ Anti-angiogenic agent Anti-resorptive agent related osteonecrosis of the jaw Everolimus

Mesh : Angiogenesis Inhibitors / adverse effects Bone Density Conservation Agents / therapeutic use Bone Neoplasms / drug therapy secondary Diphosphonates / therapeutic use Everolimus Follow-Up Studies Humans Imidazoles / therapeutic use Male Mandibular Diseases / chemically induced Middle Aged Osteonecrosis / chemically induced Sirolimus / adverse effects analogs & derivatives Thyroid Neoplasms / surgery Thyroidectomy / methods Zoledronic Acid

来  源:   DOI:10.1016/j.bjoms.2013.09.008   PDF(Sci-hub)

Abstract:
Antiresorptive agent-related osteonecrosis of the jaw results in appreciable morbidity in affected patients. Nowadays many physicians prescribe an antiangiogenic agent for the management of malignant metastases. Everolimus is a serine-threonine kinase that acts as an inhibitor of mammalian target of rapamycin, which results in reduced growth of cells, angiogenesis, and survival of cells. We report the first case to our knowledge of osteonecrosis of the jaw that seemed to result from the additive effect of everolimus.
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