关键词: Azadirachta indica Meliaceae Oleum azadirachti Pharmacology Toxicology

Mesh : Animals Azadirachta / chemistry Humans Plant Oils / pharmacology therapeutic use Seeds / chemistry Toxicology

来  源:   DOI:10.1016/S2221-1691(13)60165-3   PDF(Pubmed)

Abstract:
Oleum azadirachti consists of the oil obtained from dried seeds of Azadirachta indica A. Juss. (family: Meliaceae). Local names of Azadirachta indica A. Juss. are Abodua, aforo-oyinbo, anwe egyane, arista, azad dirakht, azadarakht, azedarach and bead tree. Indigenous to India, and widely distributed in South and South-East Asia and cultivated in Africa, the South Pacific Islands, South and Central America and Australia, and in southern Florida and California, United States of America, it is a straight-boled deciduous tree, which is 6-25 m high. Bark is dark-brown, externally fissured with a buff inner surface and fibrous fracture. Leaves alternately arranged, pinnately compound and up to 40 cm long, and composed of 8-18 short-petiolate narrow-ovate, pointed and curved toothed leaflets, 3-10 cm long and 1-4 cm wide arranged in alternate pairs. The major constituents are oxidized tetranortriterpenes including azadirachtin (azadirachtin A), azadiriadione, epoxyazadiradione, azadirone, nimbidin, nimbin, deacetylnimbin, salannin, gedunin, mahmoodin, 17-hydroxydiradione and related derivatives. It is of various medicinal uses, such as a contraceptive for intravaginal use, a mosquito repellent, and treatment of vaginal infections, treatment of gastric ulcers, cardiovascular disease, malaria, rheumatism and skin disorders, external applications for treatment of septic wounds, ulcers and boils, treatment of allergic skin reactions, asthma, bruises, colic, conjunctivitis, dysmenorrhoea, fever, gout, headache, itching due to varicella, kidney stones, leukorrhoea, psoriasis, scabies, sprains and muscular pain, and wounds. It is also used as an emmenagogue, tonic, stomatic and vermicide. In conclusion, the plant oil had antifertility, antihyperglycaemic, anti-inflammatory, antimicrobial, antiviral, antiulcer, estrogenic, immune, contraceptive, antibacterial, insect repellent, and skin treatment effects.
摘要:
印字油由从印字树A.Juss的干种子中获得的油组成。(科:蜜柳科)。AzadirachtaindicaA.Juss的本地名称.是Abodua,aforo-oyinbo,AnweEgyane,Arista,azaddirakht,azadarakht,azedarach和珠树。印度土著,广泛分布在南亚和东南亚,并在非洲种植,南太平洋群岛,南美、中美洲和澳大利亚,在南佛罗里达和加利福尼亚,美利坚合众国,它是一种直树落叶树,高6-25米。树皮是深棕色的,外部裂隙有一个浅黄色的内表面和纤维断裂。叶子交替排列,羽状化合物,长达40厘米,由8-18短叶柄窄卵形组成,尖的和弯曲的齿状小叶,长3-10厘米,宽1-4厘米,交替排列。主要成分是氧化的四氯三萜烯,包括印薄印字素(印薄印字素A),阿扎迪里酮,环氧氮杂二酮,azadirone,Nimbidin,nimbin,脱乙酰宁宾,Salannin,gedunin,mahmoodin,17-羟基二肽和相关衍生物。它有多种药用用途,例如阴道内使用的避孕药,驱蚊剂,和治疗阴道感染,治疗胃溃疡,心血管疾病,疟疾,风湿病和皮肤病,用于治疗败血症伤口的外部应用,溃疡和沸腾,治疗过敏性皮肤反应,哮喘,瘀伤,绞痛,结膜炎,痛经,发烧,痛风,头痛,水痘瘙痒,肾结石,白带,牛皮癣,疮,扭伤和肌肉疼痛,和伤口。它也被用作煽动者,补品,造口和除虫剂。总之,植物油具有抗生育作用,抗高血糖,抗炎,抗菌,抗病毒,抗溃疡,雌激素,免疫,避孕药,抗菌,驱虫剂,和皮肤治疗效果。
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