A case of oligodendroglioma with prominent neuronal differentiation.

• 影响指数: 3.526
• 发表时间: Oct 2013
• 来源期刊: Hum Pathol
• DOI: 10.1016/j.humpath.2013.02.013
• PMID: 24054724
• 文章类型: Case Reports
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Hirose T,Nobusawa S,Nakazato Y,Sasaki A

关键词: Gangliocytoma; IDH1; Neurocytoma; Neuronal differentiation; Oligodendroglioma

Mesh: Antigens, Nuclear / metabolism; Basic Helix-Loop-Helix Transcription Factors / metabolism; Biomarkers, Tumor / metabolism; Brain Neoplasms / genetics metabolism pathology surgery; Cell Transformation, Neoplastic; Combined Modality Therapy; Female; Ganglioneuroma / genetics metabolism pathology; Humans; Isocitrate Dehydrogenase / genetics; Ki-67 Antigen / metabolism; Middle Aged; Mutation; Neoplasms, Multiple Primary; Nerve Tissue Proteins / metabolism; Neurocytoma / genetics metabolism pathology; Neurons / metabolism pathology; Neurosurgical Procedures; Oligodendrocyte Transcription Factor 2; Oligodendroglioma / genetics metabolism pathology; Synaptophysin / metabolism

Abstract

We report a case of oligodendroglioma showing marked neuronal differentiation, which arose in the right frontal lobe of a 46-year-old woman. The resected tumor was composed of a mixture of oligodendroglioma, gangliocytoma, and neurocytoma areas with predominance of gangliocytoma-like areas. The oligodendroglioma areas showed immunoreactivity for Olig2 and mutant isocitrate dehydrogenase 1 protein, whereas the gangliocytoma and neurocytoma areas were positive for synaptophysin and NeuN. Ki-67 labeling index was approximately 5% to 10% in the oligodendroglioma areas. Molecular cytogenetic analyses demonstrated chromosomal losses of 1p and 19q and a mutation of isocitrate dehydrogenase 1 (G395A, R132H) in both the oligodendroglioma and gangliocytoma areas. These data suggest that this tumor is an oligodendroglioma associated with prominent neuronal differentiation. There seems to be a close relationship between oligodendroglial progenitor cells and neuronal cells.